Human Hypertension and Endothelial Cell Activation Promote the Formation and Activation of Axl+ Siglec-6+ Dendritic Cells Via Endothelial Release of Growth Arrest Specific 6

We have shown that dendritic cells (DCs) from hypertensive mice convey hypertension when adoptively transferred to recipients. Recently a novel subset of DCs in humans that express Axl and Sigelc-6+ (AS DCs) have been identified which drive T cell proliferation and produce IL-1β, IL-6 and IL-23, consistent with DCs we have observed in hypertension.