Expression of Urinary Somatic and Soluble N-Domain Isoforms Of Angiotensin Converting Enzyme and Association With Different Nutritional Status and Cardiovascular Risk Profile

Angiotensin converting enzyme (ACE) plays a dominant role in renal and cardiovascular diseases, obesity and diabetes. The somatic ACE (130-190 kDa) is composed of two homologous N- and C- domains. Two soluble N-domain isoforms have been described in human urine with 65 and 90KDa.